The 5 Best Supplements for Muscle Preservation on Ozempic: 2025 Buyer’s Guide

Master muscle preservation on Ozempic with our 2025 guide to the 5 best supplements to save your metabolism and stay lean.

Introduction

So, the scale is moving, but your reflection is looking… different. Maybe a bit softer? Maybe a bit more tired?

If you are on a GLP-1 medication, you are essentially in a race against time. While the drug melts fat, your body is looking for the easiest source of energy—and often, that’s your hard-earned muscle.

In fact, clinical reviews in 2024 and 2025 confirm that sarcopenic weight loss (muscle wasting) is the #1 threat to long-term success.

To win, you need a targeted toolkit. Here is the definitive, expert-vetted list of the best supplements for muscle preservation on Ozempic.

5 best supplements for muscle preservation on Ozempic 2025

1. The Best Protein for Low Appetite: Transparent Labs Whey Isolate

When you can barely finish a small meal, you cannot afford “filler” calories. You need the highest protein-to-calorie ratio possible.

The Secret: Most people on Ozempic struggle with “protein nausea.” Transparent Labs uses grass-fed whey with no artificial dyes or sweeteners, making it much easier on a sensitive stomach.
Why it’s for you: It delivers 28g of pure protein in a tiny 120-calorie serving.
Pro Tip: For maximum muscle preservation on Ozempic, mix this with water or almond milk—not heavy dairy—to avoid the bloat.

2. The Metabolic Insurance: Thorne Creatine Monohydrate

If there is one “must-have” on this list, it’s Creatine. It is the most researched supplement in history for a reason.

The Secret: It doesn’t just build muscle; it protects it. During a calorie deficit, Creatine helps your cells maintain energy (ATP), preventing the “muscle shedding” that causes your metabolism to crash.
Why it’s for you: Thorne is NSF Certified for Sport, meaning it’s the cleanest version on the market.
Dose: 5g daily. It’s tasteless and dissolves instantly in your morning coffee.

3. The “Ozempic Face” Buffer: 1st Phorm Collagen with Dermaval

“Ozempic Face” isn’t a myth; it’s what happens when you lose fat and collagen in your face too quickly.

The Secret: Unlike standard collagen, this contains Dermaval, which specifically supports elastin—the stuff that keeps your skin from sagging.
Why it’s for you: It supports your joints and skin while providing the amino acids necessary for muscle preservation on Ozempic.
Result: You lose the weight without looking like you’ve aged 10 years.

4. The Appetite-Gap Solution: Naked EAAs (Essential Amino Acids)

Some days, even a protein shake feels like a 5-course meal. On those days, you use EAAs.

The Secret: EAAs are “pre-digested” protein building blocks. They require zero digestion, meaning they won’t trigger nausea or that “heavy” feeling in your stomach.
Why it’s for you: They provide the 9 essential acids required for muscle preservation on Ozempic without the bulk of a shake.
Use Case: Sip them during your workout or throughout a busy afternoon.

5. The Absorption Hack: Digest Gold Digestive Enzymes

What’s the point of eating protein if your slowed-down stomach can’t process it?

The Secret: GLP-1s slow down your digestion. This often leads to protein “sitting” in the stomach, causing reflux and discomfort.
Why it’s for you: These enzymes break down proteins and fats rapidly, ensuring you actually absorb the nutrients needed for muscle preservation on Ozempic.

2025 Buyer’s Comparison Table

Product	Primary Goal	Ease of Digestion	Price Point
Transparent Labs Whey	Max Protein Hit	⭐⭐⭐⭐⭐	Check BEST Deal on Amazon
Thorne Creatine	Metabolic Speed	⭐⭐⭐⭐⭐	Check BEST Deal on Amazon
1st Phorm Collagen	Skin & Joints	⭐⭐⭐⭐	Check BEST Deal on Amazon
Naked EAAs	Low-Appetite Days	⭐⭐⭐⭐⭐	Check BEST Deal on Amazon
Digest Gold	Gut Comfort	⭐⭐⭐⭐⭐	Check BEST Deal on Amazon

supplements for muscle preservation on Ozempic 2025

Prove Me Wrong: “I can just use a cheap multivitamin.”

A multivitamin covers your micronutrients, but it does zero to stop muscle wasting. Muscle is made of amino acids and maintained by mechanical tension and cellular energy. Without the specific building blocks (Protein/EAAs) and the energy support (Creatine), your body will burn muscle. Muscle preservation on Ozempic is a physiological requirement, not an “optional extra” for bodybuilders.

If you want to be lean, firm, and healthy by 2026, start treating muscle preservation on Ozempic as the foundation of your journey, not an afterthought.

Frequently Asked Questions: The Ozempic Muscle Crisis

Does Ozempic cause muscle loss directly?

Technically, no. The medication doesn’t “attack” your muscles. However, because it suppresses your appetite so effectively, you end up in a massive calorie deficit. Without intentional muscle preservation on Ozempic, your body begins to break down muscle tissue for energy instead of just burning fat.

How much protein do I really need for muscle preservation on Ozempic?

Standard guidelines (0.8g per kg) aren’t enough when you’re on a GLP-1. Experts now recommend aiming for 1.2g to 1.5g of protein per kilogram of body weight. Since your stomach is smaller, high-quality supplements are the only way to hit this number without feeling sick.

Can I just do cardio to stay lean?

Cardio is great for your heart, but it’s terrible for muscle preservation on Ozempic if done alone. Excessive cardio in a calorie deficit actually signals your body to shed “heavy” muscle. You must include at least two days of resistance training to protect your metabolic rate.

What is the best time to take supplements for muscle preservation on Ozempic?

Consistency is key, but taking your Whey Isolate or EAAs within 30 minutes of a workout is the most effective way to signal your body to keep its lean mass. For Creatine, timing matters less than taking it every single day.

Will muscle preservation on Ozempic prevent “Ozempic Face”?

Yes. “Ozempic Face” is largely caused by the loss of facial fat and the sagging of skin due to poor protein intake. By prioritizing muscle preservation on Ozempic and using collagen, you support the structural integrity of your skin and keep a more youthful, “filled-out” appearance.

Transitioning off medication? Read our guide on weight loss maintenance after stopping Mounjaro to prevent the rebound.